Septer et al. [31] compared the prevalence of APC mutations in the population of FAP patients with thyroid cancer and the prevalence of the same mutation in the unselected FAP population and concluded that there was an increased risk of thyroid cancer in individuals with APC mutations at the 5′ end (proximal to codon 528) along with the established high-risk group harboring mutation at codon 1061. This evidence concerns the gene APC and thyroid cancer.