Meanwhile, glycosyltransferases, including chondroitin sulfate synthase 1 (CHSY1), chondroitin sulfate synthase 2 (CHSY2), chondroitin sulfate synthase 3 (CHSY3), chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1), and chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2), were highly correlated with the severity of IDD [36]. The gene discussed is CHSY1; the disease is intervertebral disk degenerative disorder.