PTGS2 and idiopathic pulmonary fibrosis: The binding of the CoREST and mSin3a transcriptional corepressor complexes, as well as the NCoR complex with the COX-2 promoter, is markedly strengthened, resulting in the insufficient acetylation of histone H3 and H4 and weakening the binding of the transcription factors NF-κB, C/EBPβ, and CREB-1 to the COX-2 promoter, eventually leading to diminished COX-2 transcription in IPF [78].