EGR1 and Hepatic fibrosis: First, TGF-β regulates p300 expression by Early Growth Response 1 (EGR1) [60, 61] and can regulate the translocation of p300 through posttranslational modification; for example, the phosphorylation of p300 by AKT signaling has been reported to induce its translocation to the nucleus in liver fibrosis [62].