CCN2 and idiopathic pulmonary fibrosis: HDAC8 inhibition at least partially represses TGF-β-induced fibrosis by increasing PPARγ gene transcription via restoration of H3K27 acetylation at the enhanced region and finally regulates CTGF, plasminogen activator inhibitor type 1 (PAI-1), and α-smooth muscle actin (α-SMA) expression in IPF [82].