FOSL2 and systemic sclerosis: Inhibition of JMJD3 ameliorated bleomycin-induced and topoI-induced fibrosis in well-tolerated doses, mechanically, inactivation of JMJD3 reduced the expression of fos-related antigen-2 (fra-2), a member of the AP1 family of transcription factors that has previously been shown to play a central role in the pathogenesis of SSc [107].