In a variety of rodent tumor models, ICD signaling has been mechanistically linked to superior responses to clinically relevant therapies, including (but not limited to) chemotherapy based on anthracycline and (some) platinum derivatives [63, 64], targeted anticancer agents specific for epidermal growth factor receptor (EGFR) [19], multitarget tyrosine kinase inhibitors [65], radiation therapy [66, 67], and photodynamic therapy [68]. This evidence concerns the gene EGFR and neoplasm.