CALR and cancer: While macrophages are surely more efficient than DCs at the latter, (1) living cancer cells tend to express high levels of anti-phagocytic molecules such as CD47 [27, 28], but much less so pro-phagocytic molecules such as calreticulin (CALR) [29], on their surface; (2) macrophages generally take up cells and their corpses in an immunologically silent manner [30, 31]; (3) macrophages have limited migratory capacity and hence do not reach lymph nodes and generally are excluded by intratumoral tertiary lymphoid structures (another site of efficient antigen presentation to T cells) [32].