In our hα-SYN mouse model of PD, expression of hα-SYN is driven by the chicken beta actin (CBA) promoter and hα-SYN protein was present in dopaminergic neurons after clenbuterol treatment discarding the possibility that β2-AR signaling is affecting the expression of hα-SYN directly in our mouse model of PD. The gene discussed is ADRB2; the disease is Parkinson disease.