Next, we tested whether reduction of NE tissue levels in the brain using DSP-4 will have the same effects on dopaminergic neuron survival in a hα-SYN mouse model of PD, where overexpression of hα-SYN is achieved using a rAAV2 virus (rAAV2–hα-SYN) (Additional file 1: Fig. S2A). This evidence concerns the gene DUSP26 and Parkinson disease.