When we conducted a subgroup analysis based on age and sex stratification (Table 5), we found that ApoA1 was closely associated with osteoporosis only among female participants [Model 1, 2 and 3, OR (95% CI), P value: 1.653 (1.103, 2.477), 0.015; 1.638 (1.092, 2.458), 0.017; 1.586 (1.053, 2.389), 0.027; respectively]. The gene discussed is APOA1; the disease is osteoporosis.