As shown in Table 2, compared to participants without osteoporosis, participants with osteoporosis had higher age, higher proportion of women, non-Hispanic White, hypertension, diabetes, gout, use of hypotensive drugs, and use of hypoglycemic drugs, and had higher levels of SBP, TG, TC, LDL-C, HDL-C, ApoA1, ApoB, BUN, FPG, HbA1c, ALP, total calcium, and lower levels of albumin and uric acid (P <  0.05). The gene discussed is APOA1; the disease is osteoporosis.