As shown in Fig. 2, ROC analysis showed that ApoA1 could predict the occurrence of osteoporosis (AUC = 0.650, P <  0.001), and we divided all participants into two groups according to the optimal cutoff point of ApoA1 obtained by ROC: lower ApoA1 group (ApoA1 ≤ 1.36 g/L) and higher ApoA1 group (ApoA1 > 1.36 g/L). This evidence concerns the gene APOA1 and osteoporosis.