As shown in Table 1, participants with higher ApoA1 had higher age, higher proportion of women, non-Hispanic Black, daily smokers, hypertension, hypercholesterolemia, osteoporosis, and lower proportion of gout, and higher levels of BMI, SBP, TC, LDL-C, HDL-C, total calcium, and lower levels of TG, BUN, CR, albumin, uric acid, FPG, CRP, ALP, and 25(OH) D compared with participants who had lower ApoA1 (P <  0.05). The gene discussed is APOA1; the disease is osteoporosis.