Under normoxic conditions, most HIF-1α proteins would be degraded by the von Hippel–Lindau tumor suppressor [8], while a few HIF-1α proteins would escape from degradation with the help of a series of protective proteins, such as ubiquitin-specific peptidase 22 [9] and BCL2-associated transcription factor 1 [10]. This evidence concerns the gene HIF1A and neoplasm.