So, healthcare providers working in the ART care service should give strong attention to female patients, people living with HIV/AIDS who have a low CD4 cell count < 200 cells/mm3) and a viral load ≥1000 copies/mL) in assessing sleep quality, Aside from that, we should care for people suffering from mental illnesses such as depression and anxiety, offer counseling services to clients, have a separate bedroom, and emphasize the importance of social support, especially when living with their families. The gene discussed is CD4; the disease is major depressive disorder.