TNF and rheumatoid arthritis: 2008) showed that aurothiomalate inhibits the extracellular release of high mobility group box chromosomal protein 1 (HMGB1) and has no effect on the secretion of tumor necrosis factor (TNF). They found that aurothiomalate inhibits the endogenous mediators of HMGH1 translocation, interferon beta (IFN-β), and nitrous oxygen (NO). HMBG1 provokes inflammation and is possibly the key process underlying the development of rheumatoid arthritis. HMBG1 is a molecule with dual function. It behaves in one way inside the cell and in another outside (Zetterström et al. 2008; Pisetsky 2017).