For example, one prior study of children presenting to an Emergency Department for an acute asthma exacerbation found differential expression of several immune-related genes including complement C3a receptor, integrin α4 (CD49d), arginase, Suppressor of Cytokine Signaling 3 (SOCS3), and interferon-mediated antiviral response genes in the transcriptomic profiles of nasal epithelial samples from the group as a whole26. The gene discussed is ITGA4; the disease is asthma.