TACC3 and breast carcinoma: To experimentally demonstrate the role of TACC3 in CC, we selected two breast cancer cell lines with CA (HER2 + cell line, JIMT-1 and TNBC cell line, MDA-MB-231), and two non-CA cell lines (luminal A cell line, MCF-7 and TNBC cell line, MDA-MB-468) as negative controls (Fig. 2B).