Overall, these data demonstrate that (i) KIFC1 and TACC3 levels strongly correlate with each other as well as with the CC score and patient survival in the context of CA, (ii) KIFC1 is a novel interactor of TACC3 in mitotic cells, and (iii) the TACC3-KIFC1 complex plays a role in mediating CC and cell survival in cancer cells with CA. The gene discussed is KIFC1; the disease is cancer.