Intriguingly, APAF1, DAPK1 and KLK10, which are among the known targets of the NuRD complex [37, 38], regulating cell cycle progression and apoptosis along with p21 and p16 were also transcriptionally activated upon TACC3 knockout or BO-264 treatment in the CA cell line, MDA-MB-231 as well as in MDA-MB-468 cells upon CA induction with cytochalasin D (Fig. 5E–G). Here, APAF1 is linked to cancer.