Notably, the “Hallmark Interferon Gamma Response” and “Hallmark TNFA Signaling via NFKB” gene signatures correlated with KEAP1 expression in melanoma CTCs (Fig. 2a) and in tumor samples and cell lines from the Cancer Genome Atlas (TCGA, Supplementary Fig. 3A, B). This evidence concerns the gene KEAP1 and neoplasm.