KEAP1 and melanoma: This effect is likely indirect, since siRNA-mediated KEAP1 knockdown in melanoma CTCs and CRISPR-mediated knockout of KEAP1 in B16-F10 mouse melanoma cells expressing ovalbumin (B16-OVA) has no effect on baseline or interferon gamma (IFNγ) induced expression of key immune markers such as PD-L1 and HLA antigen presentation molecules (Supplementary Fig. 3C–H).