This is supported by studies demonstrating upregulation of β6 in cancer cells in IDC48, as well as an upregulation of MMP13 in fibroblasts49,50,61, and can be further reinforced by data from the breast invasive carcinoma TCGA cohort, where we identify a positive correlation between expression of β6 and MMP1351. This evidence concerns the gene MMP13 and invasive breast carcinoma.