CALCR and potassium-aggravated myotonia: While we found that CALCR protein expression is upregulated in myeloid cells and TRAP+ MNGC of Npt2b−/− mice and PAM patients (Fig. 4p, r, s), we also note that CALCR is expressed in pulmonary airway epithelium (Fig. 4o, q), and has been reported in other non-myeloid compartments in kidney, uterine corpus and cardiac myocytes40.