In HPD treated Npt2b−/− mice with elevated OPG in BAL, there were fewer TRAPhi MNGCs in the lungs compared to RD and LPD treated Npt2b−/− mice, which is similar to the findings in Npt2b−/− mice treated with neutralizing RANKL antibody. The gene discussed is TNFSF11; the disease is disseminated peritoneal leiomyomatosis.