Unlike wild-type p53 which is a classic tumor suppressor, p53 mutant has oncogenic potentials [36], therefore we examined whether p53-FUCA1 axis exists in wild-type p53 (HCT116 and LoVo) and p53 mutant (DLD-1 and HT29) CRC cell lines. This evidence concerns the gene TP53 and colorectal carcinoma.