In the observation of the ultrastructure of cardiomyocytes, we noticed that altered retinol metabolism status and RDH10 expression were associated with lipid deposition (Fig. 2f, Fig. 3f, Fig. 4f, and Fig. 5f), suggesting a possible link between RDH10, disturbed retinol metabolism and myocardial lipotoxicity in DCM. The gene discussed is RDH10; the disease is familial dilated cardiomyopathy.