RDH10 and type 2 diabetes mellitus: We found in NMPCs that RDH10 deletion increased both mRNA and protein levels of CD36 by decreasing atRA (Fig. 6h), whereas the increase in cardiac CD36 in db/db mice could be restored by supplementing atRA (Fig. 6i), suggesting that in the heart in T2DM, the decrease in RDH10 and its resulting retinol metabolism disorder promotes FFAs uptake.