RDH10 and type 2 diabetes mellitus: We performed oil red O staining and cardiac triacylglyceride (TG) levels measurement and found that RDH10 deletion increased myocardial lipid deposition and TG levels whereas AAV9-RDH10 reduced myocardial lipid deposition and TG levels in db/db mice (Fig. 6a, b, e, and f), atRA but not Rol reduced myocardial lipid deposition and TG levels in db/db mice (Fig. 6c, d, and f), suggesting RDH10 reduction and its leading retinol metabolism disorder promotes lipotoxicity via atRA deficiency in the heart in T2DM.