In summary, in this study, we report for the first time that in T2DM, RDH10 reduction leads to cardiac retinol metabolism disorder characterized by Rol overload, atRA deficiency, and RARs reduction, and promotes DCM through Rol overload-induced cardiotoxicity and atRA deficiency-induced lipotoxicity and ferroptosis, as shown in Fig. 9A. Here, RDH10 is linked to familial dilated cardiomyopathy.