We found in NMPCs that RDH10 deletion increased both mRNA and protein levels of CD36 by decreasing atRA (Fig. 6h), whereas the increase in cardiac CD36 in db/db mice could be restored by supplementing atRA (Fig. 6i), suggesting that in the heart in T2DM, the decrease in RDH10 and its resulting retinol metabolism disorder promotes FFAs uptake. Here, CD36 is linked to type 2 diabetes mellitus.