HMOX1 and type 2 diabetes mellitus: In our RNA-seq data, we also found that in the hearts of db/db mice, ferroptosis-promoting genes HMOX1, MAP2LCB, ACSL1, TRF, CP, NCOA4, SLC39A8, and ALOX15 were gradually upregulated whereas ferroptosis-inhibiting gene SLC7A11 was gradually downregulated (Supplementary Fig. 7a), along with increased levels of 4-Hydroxynonenal (4-HNE), malondialdehyde (MDA) iron, and non-heme iron (indicators of iron atrophy) (Supplementary Fig. 7b-e), further confirmed the presence of ferroptosis in the heart of T2DM mice.