The mice transplanted with TG2KO bone marrow cells had markedly suppressed fibrosis regardless of whether the recipient was WT or TG2KO (Fig. 3F, H, lanes 4 and 5), indicating that TG2-dependent induction of bone marrow-derived CD11b+ F4/80hi CD206+ M2 macrophage subtypes may promote the pathogenesis of renal fibrosis. The gene discussed is TGM2; the disease is renal fibrosis.