Of note, cytokine levels in human macrophages with LPS challenge were dropped near to the baseline with SERPINA3- and SOCS1-lentivirus co-infection compared to SOCS1 alone group (Fig. 9a, b, S10m), which highlights that combination drug therapy on multiple targets might be a better approach for sepsis management in clinic. The gene discussed is SERPINA3; the disease is coinfection.