miR-122 is enriched in adipose tissue–derived exosomes; it can target VDR and interact with the BS1 region of the sterol regulatory element-binding transcription factor 1 (SREBF1) promoter to suppress VDR and SREBF1 expression, thus leading to the pathogenesis of obesity.244. Here, SREBF1 is linked to obesity due to melanocortin 4 receptor deficiency.