HDAC3 knockdown could not only regulate adipocyte pro-inflammatory profile, but also promote the expression of transcriptional regulators related to adipogenesis, including Cebpb, Cebpa, Srebf1c, and PPARγ.193 There is low HDAC6 expression in adipose tissues of humans with obesity and animal models of obesity. This evidence concerns the gene HDAC6 and obesity due to melanocortin 4 receptor deficiency.