DNMT1 and gout: Gout is caused by the deposition of MSU crystals; hence, the serum urate concentration is a risk factor to develop the disease.317 A study reported that the DNMT1 rs2228611 polymorphism may function in the development of gout, which is increased in patients with gout.318 Besides, Wang et al.319 explored gout-associated enrichment of differential DNA methylation in adaptive immunity, including pathways for B and T cell receptor signalling, IL-17 signalling, and Th17 development.