NFATC1 and type 2 diabetes mellitus: By ADP-ribosylating histone H2B at serine 7 of the NFATc1 promoter, PARP1 downregulated the expression of NFATc1, which is crucial for the macrophage differentiation into osteoclasts.215 A recent study reported that in patients with T2D, histone H3K27 crotonylation in the GLUT4 promoter region was regulated by lncRNA EPB41L4A-AS1 /GCN5 complex, which decreased the expression levels of GLUT4 and prevented glucose uptake by muscle cells.216