Besides, the result of genetic association analysis indicated that obesity is the cause of the alterations in DNA methylation levels, rather than the consequence.157 The lipid metabolism–related genes ATP-binding cassette subfamily G (WHITE) member 1 (ABCG1), carnitine palmitoyl-transferase 1 A (CPT1A), and sterol regulatory element-binding transcription factor 1 (SREBF1) show altered DNA methylation in obesity.158–161. This evidence concerns the gene SREBF1 and obesity due to melanocortin 4 receptor deficiency.