PDX1 and Hyperglycemia: Moreover, BRD9 alleviates hyperglycaemia by promoting VDR association with PBAF to change chromatin accessibility, thus restoring β cell function.220 Pdx1 is a diabetes-linked transcription factor, and SWI/SNF is essential for Pdx1 to interact with the Ins gene enhancer and then regulate the function of mature islet β cell and pancreatic progenitor cell proliferation.221 As a linker between transcription factors and the SWI/SNF core complex, BAF subunits, including BAF60a, BAF60b, and BAF60c, play a vital important role in diabetes.