POMC and obesity due to melanocortin 4 receptor deficiency: By targeting Snap25, miR-342-3p overexpression regulates NPYpSTAT3 and POMCpSTAT3 neurons, thereby leading to functional impairment in hypothalamic neurons and excess food intake.239 Similarly, miR-7 and miR-17–92, which are expressed in proopiomelanocortin (POMC)-expressing neurons in the arcuate nucleus (ARC) of the hypothalamus, are partially responsible for diet-induced obesity.