MALAT1 and Hepatic fibrosis: By increasing CXCL5 expression, MALAT1 is responsible for inflammation and fibrosis in NASH.276 Besides, expression of the lncRNA NEAT1 is elevated in carbon tetrachloride (CCl4)-induced mouse liver fibrosis models and activated hepatic stellate cells (HSCs).277 The underlying mechanism is that NEAT1 increases KLF6 expression by sponging miR-122, thus contributing to the activation of HSCs and facilitating the progress of liver fibrosis.