The expression of inflammatory mediators is induced by the elevation of critical molecules in ER stress, which regulate the JNK and NF-κB pathways.279 In addition, Platr4, an oscillating and NF-κB-related lncRNA, mitigates NASH by suppressing the NF-κB signalling pathway; this action suppresses transcription of the inflammasome components apoptosis-associated speck-like protein containing a CARD (ASC) and NOD-like receptor family pyrin domain containing 3 (NLRP3).280. The gene discussed is NFKB1; the disease is metabolic dysfunction-associated steatohepatitis.