Exosomes containing miR-223 are transported to hepatocytes and miR-223 suppresses the expression of transcriptional activator with PDZ-binding motif (TAZ), which has been acknowledged to exacerbate NASH fibrosis.248 Besides, by regulating the NF-κB–TNFα signalling pathway, miR-378 aggravates inflammation and fibrosis in the liver.249. This evidence concerns the gene TNF and metabolic dysfunction-associated steatohepatitis.