EP300 and type 1 diabetes mellitus: HDAC3 could interact with miR-296-5p to elevate the expression of Bcl-xl, resulting in the enhancement of the anti-apoptotic capacity in lymphocytes and thereby exacerbating type 1 diabetes (T1D).186 As HATs and transcriptional co-activators, CBP and its paralogue p300 play critical roles in the β cell identity and functional maturity.