MMP9 and metabolic dysfunction-associated steatotic liver disease: DOT1L interference enhances the expression of CD9 and matrix metallopeptidase 9 (MMP9), proteins associated with osteoclast fusion and resorption, but also promotes cell migration, autophagy activity, and ROS production in pre-osteoclasts.211 It is reported that the HDM plant homeodomain finger 2 (Phf2) could retard the progression of NAFLD by promoting H3K9me2 demethylation at specific gene promoters.