TP53 and type 2 diabetes mellitus: By activating TGF-β signalling, ZNF503-AS1 overexpression promotes apoptosis and suppresses proliferation.264 Yu et al.265 found that there is low expression of the lncH19 in the wound-healing cutaneous tissue of patients and mice with T2D; this state can facilitate macrophage infiltration as well as dermal fibroblast proliferation in injured skin by suppressing the activity of p53 and GDF15 releasement.