NF-κB prevents the occurrence of T1D by increasing the expression of miR-150, which downregulates the expression of p53 upregulated modulator of apoptosis (PUMA) to suppress T1D-induced inflammation and β cell apoptosis.231 miR-200c presents higher expression in islets from patients with T2D. This evidence concerns the gene TP53 and type 1 diabetes mellitus.