Metformin can reverse this effect and might serve as a potential treatment strategy.200 In addition, decreased production of reactive oxygen species (ROS) induced by the loss of CD36 aggravates the pathogenesis of NASH by upregulating monocyte chemotactic protein-1 (MCP-1) in hepatocytes, which accelerates the inflammatory response and fibrosis in the liver by facilitating macrophage migration to the liver. The gene discussed is CCL2; the disease is metabolic dysfunction-associated steatohepatitis.