APOB and metabolic dysfunction-associated steatotic liver disease: Diet plays a pivotal role in DNA methylation through several ways, including regulating the activity of enzymes associated with the one-carbon cycle and providing SAM as methyl donors.169 Recently, Chen et al.170 revealed that maternal consumption of a high-fat or high-cholesterol western diet can induce the pathogenesis of NAFLD in male offspring by modulating the expression of the apolipoprotein B (ApoB) gene.