The authors reported a disproportionate allele frequency of methylated ‘C’ between osteoporotic and healthy individuals at the -267 position from the TSS and indicated that BMP2 is hypermethylated in patients with osteoporosis.178 However, Fernandez-Rebollo et al.179 explored genome-wide DNA methylation profiles of peripheral blood from patients with primary osteoporosis and controls. The gene discussed is BMP2; the disease is osteoporosis.