GPX4 and metabolic dysfunction-associated steatotic liver disease: These miRNAs separately suppress ATP-binding cassette transporter A1 (ABCA1) and carnitine palmitoyl transferase 1 (CPT1), collaboratively inhibiting inflammation and the accumulation of lipids, thus ameliorating NAFLD.303 In addition, circ_0057558 is upregulated in NAFLD models, and the study revealed that circ_0057558 sequesters miR-206, which restores the Rho-associated kinase 1 (ROCK1)–AMPK signalling pathway and stimulated lipogenesis and TG secretion, thereby exacerbating NAFLD.304 Besides, by sponging miR-188-3p, circ_0048179 increases GPX4 levels and decelerates lipid accumulation.305