H4K16ac induced by MOF acts as a regulator to maintain glucose uptake and lipid storage in adipocytes by interacting with peroxisome proliferator-activated receptor gamma (PPARγ), thereby exacerbating the progress of obesity.192 HDAC3 affects the differentiation of adipocytes by modulating adipocyte phenotype. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.