TXNIP and type 2 diabetes mellitus: The methylation level of PHOSPHO1 is negatively correlated with the risk of T2D, while the methylation level of ABCG1 is associated with an elevated risk of T2D.365 In addition, methylation in TXNIP, SREBF1, and SOCS3 is related to the incidence of T2D.366 Johnson et al.367 identified seven CpG sites, including cg09822959 and cg19686543, which are related to liver fibrosis and could act as promising biomarkers for liver fibrosis.