miR-122 aggravates hepatic lipogenesis by targeting SIRT1 and activating the LKB1-AMPK cascade.246 Lee et al.247 revealed that hepatic miR-20b exacerbates the development of NAFLD by suppressing PPARα, which prevents mitochondrial biogenesis and FAO. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.