IFNA1 and systemic lupus erythematosus: SiMoA IFN-α measurements were highly correlated with a 6 ISG qPCR score as well as Nanostring and soluble Siglec-1.3 27 28 IFN-α protein by SiMoA correlated with cytopathic effect using Madin–Darby bovine kidney cells challenged with vesicular stomatitis virus.3 In some SLE cases, SiMoA detected IFN-α while a bioassay was negative, so the biological significance of the low IFN-α concentrations detected by SiMoA may require further confirmation.