First, we found that the expression levels of RBM15B, IGFBP2, IGFBP3 and ALKBH5 were significantly increased, while the expression levels of HNRNPC and HNRNPA2B1 were significantly decreased in AF samples compared with SR samples, suggesting that these six key m6A regulators are involved in the development of AF. The gene discussed is IGFBP2; the disease is atrial fibrillation.