HCST and nonpapillary renal cell carcinoma: On the other hand, Zhou et al. found that overexpression of immune-related genes, such as HCST, was significantly correlated with high infiltration of immune cells, especially dendritic cells, in clear cell renal cell carcinoma (ccRCC), and high expression of HCST was significantly correlated with poorer prognosis in ccRCC patients [36].