Remarkably, GNG7 has been repeatedly shown to function as a tumor suppressor in many human cancers, including head and neck squamous cell carcinoma, esophageal cancer, breast cancer, pancreatic cancer, intrahepatic cholangiocarcinoma, clear cell renal cell carcinoma, and Hodgkin lymphoma [71–80]. This evidence concerns the gene GNG7 and familial pancreatic carcinoma.