However, the tested tumor sample was negative for an activating variant in CTNNB1, and there was no evidence of monosomy 6 using a targeted DNA-based next-generation sequencing (NGS) panel (OPXv5); see Methods for additional information.1 Instead, a variant of uncertain significance was identified in SUFU (p.V148M), suggesting the possibility of a SHH-activated medulloblastoma subgroup. Here, SHH is linked to medulloblastoma.