It has been shown that POSTN upregulation in vascular smooth muscle cells can increase cell sensitivity to ferroptosis by inhibiting SLC7A11 expression, suppressing P53, and reducing GSH synthesis.[51] POSTN is also thought to be involved in airway remodeling of asthma,[52] and IL4 and IL13 can promote the expression of POSTN in airway epithelial cells. The gene discussed is IL4; the disease is asthma.