Furthermore, POSTN is considered as a marker of Th2-high asthma.[53] RNF182 increased expression in hepatocellular carcinoma can mediate p65 ubiquitination, thus accelerating the degradation of p65 protein, blocking the binding of p65 to the SLC7A11 promoter, and promoting ferroptosis.[54] In the LNCaP prostate cancer cell line, the ferroptosis inducer Erastin can increase SYT4 expression. The gene discussed is RNF182; the disease is hepatocellular carcinoma.