DE-FRGs were involved in 575 BP, 20 MF, and 13 KEGG signaling pathways, of which BP included the lipoxygenase pathway, response to oxygen levels, regulation of peptidyl-serine phosphorylation and others, KEGG pathways contained AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, HIF-1 signaling pathway, etc. The bubble diagram and bar graph displayed a part of enriched GO and KEGG pathways (Fig. 1D and E). This evidence concerns the gene RENBP and atherosclerosis.