GPX4 and asthma: However, the mitochondrial function is significantly impaired, the raw materials for intracellular synthesis of glutathione (GSH) are reduced, the glutathione peroxidase 4 is inactivated, and ROS in the cytoplasm is increased.[14] In the lung tissue of mice with house dust mite induced asthma, the glutathione peroxidase 4 and solute carrier family 7 member 11 (SLC7A11) which is an important negative regulator of ferroptosis were significantly decreased, whereas ROS levels were significantly increased, compared to normal controls.