From the ROC curve of the GSE43696 dataset, we could see that area under the curve (AUC) of DDIT4 = 0.783, NOX1 AUC = 0.82, MEF2C AUC = 0.777, NOS2 AUC = 0.715, VEGFA AUC = 0.741, and IL6 AUC = 0.715, their AUC values were all greater than 0.7, indicating that the key genes had a better ability to distinguish asthma and control. This evidence concerns the gene DDIT4 and asthma.