Ugolini–Lopes reported that IFI27 is in the type I IFN signature, which was associated with the young age of antiphospholipid syndrome.[19] Zhang et al[20] reported that OAS2 could regulate the IFN-I signaling pathway in nasal swabs and lung tissues infected with severe acute respiratory syndrome coronavirus 2. The gene discussed is IFI27; the disease is antiphospholipid syndrome.