NF-kB family was crucial for immune responses and inflammation and NF-kB has been implicated in the initiation, progression and resistance to treatment in human cancers.[34] JAK-STAT signaling pathway is essential to tumor cell proliferation, metastasis, inflammation, and immune response in breast cancer.[35,36] Cell adhesion molecules also play a significant role in breast cancer cell invasion and metastasis.[37] Therefore, STAT5B may affect the tumorigenesis and progress of breast cancer by mediating these signaling pathways. Here, STAT5B is linked to cancer.