KRAS and colorectal carcinoma: Some large multicenter cohorts have indicated that CRC patients bearing G12V or G12C had worse OS prognoses than wild-type KRAS tumors.[17,18] However, KRAS mutation variants G12V and G12D had no impact on survival in univariate and multivariate analyses.[19] We also did not observe difference in the impact of KRAS mutation variants G13D, G12D, or G12A on OS in our study (P = .705, P = .487, respectively) (Supplementary Figure S2, Supplemental Digital Content, http://links.lww.com/MD/I561 and Supplementary Figure S3, Supplemental Digital Content, http://links.lww.com/MD/I562).