During pyroptosis, inflammasomes perceive danger signaling and cellular events, eliciting caspase activation, Gasdermin D cleavage, and release of IL-18 and IL-1β.[4] And it can suppress tumor occurrence and progression, while forming a microenvironment for providing nutrients to cancer tissues and promoting tumor growth.[5] Emerging evidence shows that it functions in tumor cell proliferation, invasion, and migration, influencing cancer prognosis.[6,7] For instances, pyroptosis induces apoptosis of tumor cells in digestive tract. Here, GSDMD is linked to neoplasm.