HMGB1 and neoplasm: Among them, 32 were identified as the DEGs, of which 4 (NLRP2, NLRP7, NLRP1, and PRKACA) were downregulated and the remaining 28 (CHMP6, CASP9, SCAF11, HMP4A, HMGB1, CHMP2A, IRF2, BAK1, NOD1, NLRC4, CASP8, GSDME, IRF1, BAX, CASP3, GZMB, IL18, PYCARD, gasdermin D (GSDMD), CASP6, CASP5, NOD2, TP53, AIM2, GSDMA, CASP1, CASP4, and GZMA) were up-regulated in the tumor samples (Fig. 2A).