Recent researches have shown that activated CASP1 could cleave C1q binding protein and boost aerobic glycolysis in tumor cells.[14] Upon activation, CASP3 can cleave GSDME to induce necrosis, providing novel insights into malignant tumor chemotherapy.[15]CASP8 has been defined as a molecular switch that regulates apoptosis, necroptosis, and pyroptosis; its activation participated in inflammatory responses of COVID-19 patients, probably causing lung injury.[16,17]NLRP1 is abundant in epithelial barrier tissues. This evidence concerns the gene GSDME and COVID-19.