And it can lead to the release of inflammatory factors while transforming normal cells into malignant ones.[22] Pyroptosis may potentially be used for prognostic prediction and treatment of malignant tumors.[23] Herein, we divided a TCGA cohort of GBM cases into 2 groups based on the expression level of 52 PRGs and identified 32 DEGs between them. The gene discussed is GART; the disease is cancer.