IRS1 and neoplasm: In cancer, miR-126 can inhibit the growth of tumor cells, metastasis, by inhibiting a series of important genetic targets (such as PI3K, KRAS, EGFL7, CRK, ADAM9, HOXA9, IRS-1, SOX-2, SLC7A5, and VEGF).[8,15,19,20] Functions such as death, invasion and metastasis.