ORAI1 and hereditary disease: Our results are interesting because of the widespread attention gained by SOCE in skeletal muscle, not only because mutations in STIM1 and ORAI1 are the underlying feature of several genetic diseases associated with muscle weakness (Böhm et al., 2013; Lacruz and Feske, 2015), but also because experimental evidence has shown that Stim1 and Orai1 play an important role in refilling intracellular calcium stores in fast and slow twitch muscles (Cully et al., 2016; Wei-Lapierre et al., 2013; Carrell et al., 2016).