Since ophthalmoplegia is a common clinical sign observed in patients affect by congenital myopathies linked to recessive RYR1 mutations (Lawal et al., 2018; Amburgey et al., 2013; Jungbluth et al., 2018), we also investigated the proteome of EOMs from dHT and WT mice. The gene discussed is RYR1; the disease is ophthalmoplegia.