EPAS1 and neoplasm: Primary tumor weight, tumor burden, and lung metastases are elevated in mice with flank tumors derived from acetylation-intact (K3) HIF-2α and nuclear-localizable (WT) Acss2 knockdown/rescue cells relative to mice with flank tumors derived from acetylation-defective (R3) HIF-2α or cytosol-restricted (ED) knockdown/rescue cells (Figs 7E–7G and 8E–8G), respectively.