HIF-2 selective or co-regulated target genes associated with tumor growth and metastasis (VEGFa, PAI1, MMP9, GLUT1) were induced in acetylation-intact (K3) HIF-2α and nuclear-localizable (WT) Acss2 knockdown/rescue cells under hypoxia and low glucose conditions. Here, EPAS1 is linked to neoplasm.