To our knowledge, this is the first study using the Pentraxin-3 assay on the MSD Quickplex 120 platform showing a near to zero pg/ml concentration of PTX3 in CSF in a control group and concurrent highly elevated CSF PTX3 in patients with bacterial meningitis, viral meningitis, and viral encephalitis. The gene discussed is PTX3; the disease is viral meningitis.