CRP and SAP are primarily produced in the liver, mainly by IL-6 induction in response to infection or inflammation, whereas PTX3 is mainly induced by IL-1 and TNF-α and produced by a variety of cells such as macrophages, endothelial cells, and dendritic cells and preserved in neutrophils for rapid distribution [10, 12, 13]. The gene discussed is TNF; the disease is infection.