CRP and encephalitis: Buch et al. [28], investigated the known clinically used biomarkers (CSF leukocytes, CSF neutrophil fraction, CSF protein, CSF glucose ratio, Plasma-CRP, and CSF lactate) for distinguishing between acute bacterial meningitis and acute viral meningitis/encephalitis and found that CSF lactate with ROC AUC 0,976, sensitivity 96%, specificity 85%, PPV 72% and NPV 98% performed better than other CSF biochemistry.