CSF PTX3 in patients with encephalitis (HSV-1 and 2, n = 5; VZV, n = 1; TBE, n = 4) were significantly higher than among control group patients also when including encephalitis with an unknown pathogen (p = 0.027 and p = 0.004, respectively). This evidence concerns the gene PTX3 and tick-borne encephalitis.