Prior to the publication of the 2 manuscripts cited above [9,10] identifying the SMC5/6 complex as essential for the epigenetic silencing of unintegrated HIV-1 DNA, the Goff laboratory reported that the human silencing hub (HUSH) complex, consisting of MPP8, TASOR, and PPHLN1, acting in concert with a DNA-binding protein called NP220, was required for the epigenetic silencing of unintegrated DNA generated upon infection of human cells by the animal retrovirus murine leukemia virus (MLV) [12]. The gene discussed is SMC5; the disease is infection.