l-type amino acid transporter 1 (LAT1), encoded by solute carrier transporter 7a5 (Slc7a5), is a Na+-independent amino acid transporter that facilitates the cellular uptake of large neutral amino acids, including BCAAs and aromatic amino acids (18, 19), and plays a crucial role in amino acid sensing and signaling in specific cell types (20, 21), contributing to the pathogenesis of cancer and neurological disorders (22, 23). The gene discussed is LAT; the disease is cancer.