The SLC20A2 gene, located on chromosome 8 (8p11.21), codes for the type III Na-dependent inorganic phosphate (Pi) transporter 2 (PiT2), which is strongly expressed in neurons, but also in astrocytes and endothelial cells in parts of the brain commonly affected by PFBC, such as basal ganglia. Here, SLC20A2 is linked to bilateral striopallidodentate calcinosis.