In a murine model of PFBC due to PDGFB mutations, Zarb et al. [12] characterized the cellular environment surrounding calcifications, demonstrating that cells around vessel-associated calcifications express markers for osteoblasts, osteoclasts and osteocytes, leading to the presence of an osteogenic environment and a progressive ossification process at the NVU. The gene discussed is PDGFB; the disease is bilateral striopallidodentate calcinosis.