CALR and autoimmune disease: NucPrs that are often targeted in autoimmune diseases by auto-Abs include nucleosomal histones, SS-A/Ro, RNP-Sm (small nuclear ribonucleoproteins), Scl70, and Jo-1 (aminoacyl-tRNA synthetase, both nuclear and cytoplasmic) (Mahler and Fritzler, 2010; Tan, 1983).