TFRC and Autoimmunity: On one side, Tfr prevent development of auto-Abs and autoimmunity (Botta et al., 2017; Clement et al., 2019; Fu et al., 2018; Gonzalez-Figueroa et al., 2021; Wu et al., 2016) and in some studies appear to have a modest negative effect on the GC and Ab response (Chung et al., 2011; Clement et al., 2019; Fu et al., 2018; Sage et al., 2016; Wollenberg et al., 2011).