DIO2 and squamous cell carcinoma: We found that late-stage squamous cell cancer (SCC) increases D2 expression to increase intracellular T3 levels: T3 treatment increased the invasiveness of advanced SCC while, in the opposite direction, D2 depletion attenuated the metastases formation, revealing that D2-derived T3 is needed for SCC progression (Miro et al. 2019, Nappi et al. 2020).