Moreover, the EGFR family includes three additional members (ERBB2, −3 and −4), often expressed by CRC cells and able to form any kind of functional heterodimers upon binding to two distinct ligand families (EGF‐like factors, binding to EGFR, and neuregulins binding to ERBB3 or −4) [44]. The gene discussed is EGF; the disease is colorectal carcinoma.