Psychological insulin resistance is defined as resistance to insulin therapy both on the part of patients and healthcare workers.8 Patients may be concerned about gaining weight, dose calculations, storage and transportation of insulin, restricted social activities and self-injection.9 Clinicians may also be concerned with insulin storage, transportation and dose calculation.10 Insulin initiation is often perceived as a last resort, rather than an inevitability, and some clinicians regard it as a failure of lifestyle modification. This evidence concerns the gene INS and Insulin resistance.