In addition, there are recent publications in the literature that commercial zonulin ELISA kits do not reflect intestinal permeability.24 Although the inadequacy of zonulin in demonstrating the development of infected necrosis seems to be associated with this, the evaluation by Alessio Fasano shows that the measurement of the zonulin family of proteins is still a good indicator of intestinal permeability.25 According to our results, which are the first in the literature, low zonulin levels in patients with AP may be associated with the development of pancreatic complications. This evidence concerns the gene HP and alkaline phosphatase measurement.