In an experimental study conducted by Huang et al.8 no significant difference was found in the levels of ZO-1, a tight junction protein, in the acute necrotizing pancreatitis group.8 In another study, it was shown that occludin and ZO-1 expression in the intestinal tissue decreased in experimental acute severe pancreatitis.22 Sonika et al23 demonstrated that the intestinal permeability increased in patients with AP. Here, OCLN is linked to alkaline phosphatase measurement.