To test the “delayed kinetics” hypothesis, we injected WT and Calhm6−/− mice with L. monocytogenes i.p. and analysed NK activation, either early, 18 h post‐infection when IFN‐γ production from NK cells is at its peak in WT mice (Kubota & Kadoya, 2011), or late, 3 days post‐infection, to detect delayed NK cell activity. Here, CALHM6 is linked to infection.