Using the clonally induced scrib mutant, oncogenic Ras (RasV12) model of epithelial tumourigenesis (Brumby and Richardson, 2003; Leong et al., 2009), we have previously shown that feeding tumour-bearing larvae a bioavailable compound (PD0325901) that targets MEK (Drosophila Dsor1), a protein kinase in the Ras-MAPK pathway, was effective in reducing tumour size (Willoughby et al., 2013). Here, SCRIB is linked to neoplasm.