DGKA and neoplasm: As Drosophila Ras-driven, polarity-impaired tumours have unrestrained activity of aPKC [an important factor in inducing tumour growth (Leong et al., 2009)], which occurs via Hippo pathway inhibition (Doggett et al., 2011), it is possible that by inhibiting DGKα, the elevated aPKC activity and Hippo pathway impairment would be rescued.