SOAT1 and neoplasm: We then analysed the effect of the drug combination on other important signalling pathways involved in Ras-driven polarity-impaired tumour growth in Drosophila and mammalian cells: PI3K signalling-induced cell proliferation, JAK-STAT signalling-induced cell proliferation, Hippo signalling-induced negative tissue growth, and P38 stress-response pathways (Bunker et al., 2015; Doggett et al., 2011; La Marca and Richardson, 2020; La Marca et al., 2021; Norman et al., 2012; Richardson and Portela, 2017; Stephens et al., 2018).