However, when RasV12 is expressed within epithelial tissues that are also mutant for scrib, neoplastic tumours are generated, which show increased cell proliferation, increased survival, reduced differentiation and invasive/metastatic behaviour, thereby replicating many of the mammalian cancer hallmarks (Brumby and Richardson, 2003; Leong et al., 2009; Pagliarini and Xu, 2003). This evidence concerns the gene SCRIB and cancer.