A group of genes heavily implicated in human cancers are the oncogenic RAS genes, which signal through the RAF-MEK-MAPK and phospho-inositol-3-kinase (PI3K)-AKT-mechanistic target of rapamycin (mTOR) pathways to drive cell growth, proliferation and survival (Malumbres and Barbacid, 2003; Pylayeva-Gupta et al., 2011). The gene discussed is MAP2K7; the disease is cancer.