Louis and Coulouarn54 have found that circACTN4 upregulates YAP1 expression by sponging miR-424-5p, and recruits Y-box binding protein 1 (YBX1), thus initiating FZD7 transcription and promoting intrahepatic cholangiocarcinoma progression. The gene discussed is YBX1; the disease is intrahepatic cholangiocarcinoma.