Although pancreatic cancer risks were not shown to be significantly elevated in female relatives of BRCA1 or BRCA2 carriers, a trend toward risk for pancreatic cancer was still observed for female relatives of BRCA2 carriers (RR 2.54, 95% CI 1.02-6.30; P = 0.055). This evidence concerns the gene BRCA1 and familial pancreatic carcinoma.