The risks for breast (RR = 4.19, 95% CI = 3.53-4.98; P < 0.001) and ovarian cancers (RR = 4.65, 95% CI = 2.22-9.73; P = 0.001) in female relatives of BRCA2 carriers were also significantly higher than female relatives of non-carriers. The gene discussed is BRCA2; the disease is ovarian carcinoma.