BRCA1 and cancer: Female relatives of BRCA1 carriers had significantly higher risks for ovarian (RR = 4.72, 95% CI = 2.16-10.31; P < 0.001), liver (RR = 6.30, 95% CI = 1.35-29.36; P = 0.016), and any cancers (RR = 1.22, 95% CI = 1.02-1.46; P = 0.032) than female relatives of BRCA2 carriers (Table 2).