As EXOCS2 is an essential gene in 1,076/1,086 cancer cell lines in the Cancer Dependencies Map project (depmap.org) including all 19 myeloma cell lines in the dataset, a future approach would be to engineer the EXOSC2 M40T mutation into myeloma cell lines to determine the effects on RNA exosome function as well as myeloma cell growth and survival. The gene discussed is EXOSC2; the disease is cancer.