EXOSC2 and plasma cell myeloma: As EXOCS2 is an essential gene in 1,076/1,086 cancer cell lines in the Cancer Dependencies Map project (depmap.org) including all 19 myeloma cell lines in the dataset, a future approach would be to engineer the EXOSC2 M40T mutation into myeloma cell lines to determine the effects on RNA exosome function as well as myeloma cell growth and survival.