In parallel, a significant increase of the immunosuppressive cytokine interleukin (IL)‐10 and a trend towards reduced tumour necrosis factor (TNF) expression was noticed in SHP‐deficient mice at the peak of DSS colitis at day 7, while LRH‐1 expression was not different (Fig. 4H–J). This evidence concerns the gene NR5A2 and colitis.