To analyse these processes independently of the initial tumour‐promoting inflammatory phase during the chronic colitis, we isolated tumours from wild‐type mice, LRH‐1‐deficient or SHP‐deficient mice at day 56, and expanded tumour cells in 3D cultures resulting in tumour organoids (tumoroids) (Fig. 6A, Fig. S2A). Here, NR5A2 is linked to colitis.