CASP1 and central nervous system cancer: Figure 8C showed the GSDMD-dependent pyroptosis signaling pathway. After GSDMD knockdown in glioma cells, the expression of IL-1β, cleaved caspase-1 and GSDMD-NT decreased, and the expression level of pro-caspase-1 was not affected (Figure 8D). We also evaluated the survival of glioma patients using TCGA data and found that the expression level of GSDMD was significantly associated with poor prognosis (Figure 8E).