In Figures 3B–E, a comparison between RA-LJ and OA reveals two key modules with 14 upregulated genes (CST7, CD8A, GEMK, GZMH, GZMA, GZMB, PRF1, CD3D, CXCL9, NKG7, CD2, CD247, ITGAL, CCL5) and three downregulated genes (SOX8, ZIC1, and POU3F3). The gene discussed is CD8A; the disease is rheumatoid arthritis.