In Figures 3B–E, a comparison between RA-LJ and OA reveals two key modules with 14 upregulated genes (CST7, CD8A, GEMK, GZMH, GZMA, GZMB, PRF1, CD3D, CXCL9, NKG7, CD2, CD247, ITGAL, CCL5) and three downregulated genes (SOX8, ZIC1, and POU3F3). This evidence concerns the gene GZMB and rheumatoid arthritis.