A recent study by Butterfield et al. identified 14 genes involved in osteoarthritis pathogenesis, including Pitx1, and functionally characterize 6 candidate human osteoarthritis genes (Unk, Josd1, Gsdme, Arhgap30, Ccdc6, and Col4a2) in mouse models (Butterfield et al., 2021), revealing the genetic basis for osteoarthritis. This evidence concerns the gene ARHGAP30 and osteoarthritis.