The pathological hallmarks of AD include the deposition of extracellular β-amyloid (Aβ) aggregates in the brain parenchyma as senile plaques and within the cerebral vessel walls and leptomeninges as cerebral amyloid angiopathy, along with intracellular hyperphosphorylated tau aggregates as neurofibrillary tangles, and neuronal cell loss as neurodegeneration (Jack et al., 2018). Here, MAPT is linked to Alzheimer disease.