PRICKLE1 and esophageal cancer: Through experimental validation, we found that the expression of PRICKLE1 was reduced in esophageal cancer; PRICKLE1 was able to attenuate Wnt/β-catenin signaling; and the cell viability was reduced, the migration ability was significantly reduced and the apoptosis rate was significantly higher in the PRICKLE1-OE group compared with the NC group.This indicates that PRICKLE1 is closely related to the development of ESCC cells.