PRICKLE1 and esophageal cancer: Through experimental validation, we found that the expression of PRICKLE1 was reduced in esophageal cancer; PRICKLE1 was able to attenuate Wnt/β-catenin signaling; the cell viability was reduced, the migration ability was significantly lower and the apoptosis rate was significantly higher in the PRICKLE1-OE group compared with the NC group (Figures 5A–F, P<0.05).